Primarily referred to in the United States as Epinephrine and norepinephrine , Adrenaline and noradrenaline are catecholamines , water-soluble compounds that have a structure made of a catechol group and an amine group . The adrenal glands are responsible for most of the adrenaline that circulates in the body, but only for a small amount of circulating noradrenaline.  These hormones are released by the adrenal medulla, which contains a dense network of blood vessels. Adrenaline and noradrenaline act at adrenoreceptors throughout the body, with effects that include an increase in blood pressure and heart rate.  actions of adrenaline and noradrenaline are responsible for the fight or flight response , characterised by a quickening of breathing and heart rate, an increase in blood pressure, and constriction of blood vessels in many parts of the body. 
The symptoms, disabilities and life-style of a person with Cushing’s Syndrome depend on the degree of cortisol excess, the duration of the disease, the basic health of the person, but especially the type and curability of the Cushing’s Syndrome. If it is cured, all of the features of the disease can resolve, but this may take as long as 2 to 18 months. During that time, most people get annoyed and frustrated by the slow improvements in physical changes and the combination of Cushing’s and adrenal insufficiency signs and symptoms (dizziness, weakness, nausea, loss of appetite) as replacement steroid hormones are tapered and adrenal hormone production slowly improves toward normal. Frequent calls and visits to physicians are necessary.