Adverse effects of corticosteroids in pregnancy

Back, abdominal, or stomach pain an adverse change in vision, coughing, shortness of breath, troubled breathing, tightness in the chest, or wheezing, discharge from the eye, dizziness, eye or eyelid pain, swelling, discomfort, or irritation, increased blood pressure, increased frequency of urination or painful urination, itching of the eyelid, seeing flashes or sparks of light, seeing floating spots before the eyes, swelling of lining of the eyelid, tiny bumps on lining of the eyelid, blistering, peeling, or loosening of the skin, blood in the urine, blue lips, fingernails, or skin, chest pain or discomfort, chills, cough, diarrhoea, difficult or troubled breathing, fainting, headache or weakness, severe and sudden, irregular, fast or slow, or shallow breathing, itching, joint or muscle pain, light-headedness, mental depression, nausea or vomiting, pain, numbness, tingling, or burning feeling in the hands or feet, red, irritated eyes, red skin lesions, often with a purple center, shortness of breath, skin rash,, slow or irregular heartbeat, sore throat, sores, ulcers, or white spots in the mouth or on the lips, sweating, unusual tiredness or weakness, cold- or flu-like symptoms, crusting or scales on eyelid, dryness of the eyes, indigestion or an upset stomach, a sore throat, a stuffy or runny nose, tearing of the eye, a burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings, depression, a dry mouth and/ or a stuffy nose.

In a multigenerational developmental study in pregnant rats given oral gavage doses of , 1, 3 g/kg/day ethyl-EPA from gestation day 7-17, an increased incidence of absent optic nerves and unilateral testes atrophy were observed at ≥ g/kg/day at human systemic exposure following an oral dose of 4 g/day based on body surface area comparisons across species. Additional variations consisting of early incisor eruption and increased percent cervical ribs were observed at the same exposures. Pups from high dose treated dams exhibited decreased copulation rates, delayed estrus, decreased implantations and decreased surviving fetuses (F2) suggesting multigenerational effects of ethyl-EPA at 7 times human systemic exposure following 4 g/day dose based on body surface area comparisons across species.

Adverse effects of corticosteroids in pregnancy

adverse effects of corticosteroids in pregnancy

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