Antenatal steroids after 34 weeks

Main results  Seven observational studies were included. In histological chorioamnionitis (five studies), antenatal steroids were associated with reduced mortality (OR = ; 95% CI = –; P  = ), respiratory distress syndrome (OR = ; 95% CI = –; P  < ), patent ductus arteriosus (OR = ; 95% CI = –; P  = ), intraventricular haemorrhage (IVH; OR = ; 95% CI = –; P  = ) and severe IVH (OR = ; 95% CI = –; P  = ). In clinical chorioamnionitis (four studies), antenatal steroids were associated with reduced severe IVH (OR = ; 95% CI = –; P  = ) and periventricular leucomalacia (OR = ; 95% CI = –; P  = ).

Corresponding authors were contacted to obtain crude data when percentages were used, 3,5,14 and to obtain additional information on antenatal steroid administration (preparation, dose, dosing scheme). 3,13,15,16 Several responded and supplied additional information. 3,13,15,16 A 10% cohort overlap between the studies by Foix-L’Helias et al. and Baud et al. was reported. 13,15 This was not accounted for in the meta-analysis, and thus may slightly affect the pooled estimate on RDS after clinical chorioamnionitis.

Antenatal steroids after 34 weeks

antenatal steroids after 34 weeks

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