OMG….This sounds exactly like my situation! Funny how you will go so far as to actually show a loved one one of these things in an attempt to justify your actions as well as to protect them from this nightmare, and they shrug it off like it’s no big deal, or you’re just being paranoid! Ive been dealing with this shit for over a year now, and I’m here to tell you this shit ain’t no joke!! There isn’t a single place on the body these things won’t get! I have also had them in my eyes, nose, mouth, ears, gums, you name it! Anybody that tells you any different, dont know what the fuck they’re talking about! Know that!!! My heart and prayers go out to anyone dealing with this nightmare!
Phosphorylation of the E2F-1-DP-1 heterodimer by cyclin B-dependent kinases, however, did not result in down-regulation of its DNA-binding activity, as is readily seen after phosphorylation by cyclin A-dependent kinases, suggesting that phosphorylation per se is not sufficient to regulate E2F DNA-binding activity. Depending on the pH of the growth medium, the yeast Yarrowia lipolytica secretes both an acidic proteinase and an alkaline proteinase, the synthesis of which is also controlled by carbon, nitrogen, and sulfur availability, as well as by the presence of extracellular proteins.
A. FDA is finalizing those changes that are based on proposals it made in earlier stages of rulemaking, including a 2007 proposed rule, on which it already received public comment. Those comments also helped to inform the Agency's thinking about additional aspects of sunscreen regulation, which in turn gave rise to the Proposed Rule and Advance Notice of Proposed Rulemaking (ANPR). The regulatory process requires FDA to give public notice and opportunity for comment before finalizing additional changes, which also gives the public and FDA an opportunity to further develop the record (data and information) on safety and effectiveness.