Bradycardia and Conduction Disturbances: Bradycardia, sinus arrest and heart block have occurred with Corlanor ® . The rate of bradycardia in patients treated with Corlanor ® compared to placebo was 6% (% symptomatic; % asymptomatic) vs. % per patient‐year, respectively. Risk factors for bradycardia include sinus node dysfunction, conduction defects, ventricular dyssynchrony, and use of other negative chronotropes. Bradycardia may increase the risk of QT prolongation which may lead to severe ventricular arrhythmias, including torsades de pointes, especially in patients with risk factors such as use of QTc prolonging drugs.
Salicylates are derivatives of salicylic acid that occur naturally in plants and serve as a natural immune hormone and preservative , protecting the plants against diseases , insects , fungi , and harmful bacteria . [ citation needed ] Salicylates can also be found in many medications , perfumes and preservatives. [ citation needed ] Both natural and synthetic salicylates can cause health problems in anyone when consumed in large doses, [ citation needed ] but for those who exhibit salicylate sensitivity (also known as salicylate intolerance ), even small doses of salicylate can cause adverse reactions.
A proposed nationwide Settlement has been preliminarily approved in a class action lawsuit involving certain Remington firearms. The class action lawsuit claims that trigger mechanisms with a component part known as a trigger connector are defectively designed and can result in accidental discharges without the trigger being pulled. The lawsuit further claims that from May 1, 2006 to April 9, 2014, the X-Mark Pro® trigger mechanism assembly process created the potential for the application of an excess amount of bonding agent, which could cause Model 700 or Seven bolt-action rifles containing such trigger mechanisms to discharge without a trigger pull under certain limited conditions. The lawsuit contends that the value and utility of these firearms have been diminished as a result of these alleged defects. Defendants deny any wrongdoing.