Predmet 4 steroid

METHYL PREDNISOLONE : Decreases effect of anticholinesterases in myasthenia gravis. May decrease the hypoglycaemic effects of antidiabetic agents. Decreases serum concentrations of salicylates. Increased hypokalemic effects of potassium-depleting diuretics (thiazides or furosemide), amphotericin B, bronchodilator therapy with xanthines or ß2 agonists. Increase incidence of GI bleeding and ulceration with NSAIDs. May increase the anticoagulant effects of warfarin. Decreased levels/effects with CYP3A4 inducers (aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins). Increased levels/effects with CYP3A4 inhibitors (azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, and verapamil). May decrease the effects of vaccines (dead organism) or increase the risk of vaccinal infection (live organism). Antacids and bile sequestrants may decrease the absorption of corticosteroids, separate admin by 2 hr. Increased risk of myopathy with neuromuscular-blocking agents, tendinopathies with fluoroquinolones.

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chicken pox and measles , for example, can have a more serious or even fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases particular care should be taken to avoid exposure. How the dose, route and duration of corticosteroid administration affects the risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed, to chicken pox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chicken pox develops, treatment with antiviral agents may be considered. Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) infestation. In such patients, corticosteroid-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia .

I have this constant sound in ears more in left ear and feel comming from centre of the head. It will be more after having nap in afternoon. I feel suddenly hungry in afternoon and dizziness, weakness in legs and fainting like situation. I should eat food immediately. I have anxiety disorders since three years. I used to take ashwagandha every morning after breakfast. I was feeling better with ashwagandha for anxiety. i feel heavy headedness and lethargy. I have lost inetrest in things. I worry a lot on silly issues. my food intake is ok and i walk in mornings and other activities are normal. i have knee pain and lower back pain after sitting in front computers for long time. If i am walking i dont feel any pain. i have palpitations some times. sleep is less.

Predmet 4 steroid

predmet 4 steroid

I have this constant sound in ears more in left ear and feel comming from centre of the head. It will be more after having nap in afternoon. I feel suddenly hungry in afternoon and dizziness, weakness in legs and fainting like situation. I should eat food immediately. I have anxiety disorders since three years. I used to take ashwagandha every morning after breakfast. I was feeling better with ashwagandha for anxiety. i feel heavy headedness and lethargy. I have lost inetrest in things. I worry a lot on silly issues. my food intake is ok and i walk in mornings and other activities are normal. i have knee pain and lower back pain after sitting in front computers for long time. If i am walking i dont feel any pain. i have palpitations some times. sleep is less.

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