Steroidal drugs wikipedia

Microbial catabolism of phytosterol side chains yields C-19 steroids, C-22 steroids, and 17-ketosteroids (. precursors to adrenocortical hormones and contraceptives ). [46] [47] [48] [49] The addition and modification of functional groups is key when producing the wide variety of medications available within this chemical classification. These modifications are performed using conventional organic synthesis and/or biotransformation techniques. [50] [51]

NSAIDs are not recommended during pregnancy, particularly during the third trimester . While NSAIDs as a class are not direct teratogens , they may cause premature closure of the fetal ductus arteriosus and kidney ADRs in the fetus. Additionally, they are linked with premature birth [63] and miscarriage . [64] [65] Aspirin, however, is used together with heparin in pregnant women with antiphospholipid antibodies . [66] Additionally, indomethacin is used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal kidney blood flow.

Steroidal drugs wikipedia

steroidal drugs wikipedia

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